The APOE^∗3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis.

ABSTRACT:

Background

There is a lack of predictive preclinical animal models combining atherosclerosis and type 2 diabetes. APOE∗3-Leiden (E3L) mice are a well-established model for diet-induced hyperlipidemia and atherosclerosis, and glucokinase^+/- (GK^+/-) mice are a translatable disease model for glucose control in type 2 diabetes. The respective mice respond similarly to lipid-lowering and antidiabetic drugs as humans. The objective of this study was to evaluate/characterize the APOE^∗3-Leiden.glucokinase^+/- (E3L.GK^+/-) mouse as a novel disease model to study the metabolic syndrome and diabetic complications.

Methods

Female E3L.GK^+/-, E3L, and GK^+/- mice were fed fat- and cholesterol-containing diets for 37

SUBMITTER: Pouwer MG 

PROVIDER: S-EPMC6425338 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature