Gender specific click and tone burst evoked ABR datasets from mice lacking the Ca_v3.2 T-type voltage-gated calcium channel.

ABSTRACT:

Objectives

Voltage-gated Ca²⁺ channels (VGCCs) are of central relevance in regulating Ca²⁺ influx into living cells. The low-voltage activated (LVA) Ca_v3 T-type Ca²⁺ channels are widely distributed throughout the brain including the peripheral auditory system and ascending auditory tract. Their exact role in auditory information processing is still not fully understood. Within the LVA subgroup, Ca_v3.2 T-type Ca²⁺ channels seem to be of special importance as qPCR revealed a steady increase in Ca_v3.2 transcript levels over age, e.g. in the cochlea and spiral ganglion neurons (SGN). Furthermore, pharmacological studies suggested an association between Ca_v3.2 expression and both age-related and nois

SUBMITTER: Lundt A 

PROVIDER: S-EPMC6425560 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature