Altered PGE2-EP2 is associated with an excessive immune response in HBV-related acute-on-chronic liver failure.

ABSTRACT: BACKGROUND AND AIMS:Prostaglandin E receptor 2 (EP2) is an immune modulatory molecule that regulates the balance of immunity. Here we investigated the role of EP2 in immune dysregulation in patients with acute-on-chronic liver failure (ACLF). METHODS:Plasma Progstaglandin E2 (PGE2) levels and EP2 expression on immune cells were determined in blood samples collected from patients with chronic hepatitis B related ACLF(HB-ACLF), patients with chronic hepatitis B (CHB), acute decompensated cirrhosis without ACLF (AD) and healthy controls (HC). Cytokine production, bacterial phagocytosis and reactive oxygen species (ROS) production were detected to explore the role of EP2 in regulating immune cell functions. RESULTS:The plasma PGE2 levels were increased and EP2 expression on CD8+ T cells was de

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6425563 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature