FitTetra 2.0 - improved genotype calling for tetraploids with multiple population and parental data support.

ABSTRACT:

Background

Genetic studies in tetraploids are lagging behind in comparison with studies of diploids as the complex genetics of tetraploids require much more elaborated computational methodologies. Recent advancements in development of molecular techniques and computational tools facilitate new methods for automated, high-throughput genotype calling in tetraploid species. We report on the upgrade of the widely-used fitTetra software aiming to improve its accuracy, which to date is hampered by technical artefacts in the data.

Results

Our upgrade of the fitTetra package is designed for a more accurate modelling of complex collections of samples. The package fits a mixture model where some parameters of the model are estimated separately for each sub-collection. When a full-sib

SUBMITTER: Zych K 

PROVIDER: S-EPMC6425654 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature