Histochemical Analysis of Glaucoma Caused by a Myocilin Mutation in a Human Donor Eye.

ABSTRACT:

Objective

Mutations in myocilin (MYOC) may cause either juvenile open angle glaucoma (JOAG) or adult-onset primary open angle glaucoma (POAG). MYOC encodes a glycoprotein that is normally secreted from trabecular meshwork cells that regulate intraocular pressure. Prior in vitro, transgenic rodent, and organ culture experiments have suggested that abnormal accumulation of MYOC protein within trabecular meshwork cells is a key step in glaucoma pathophysiology. We investigated the pathogenesis of MYOC glaucoma by examining a donor eye from a patient with JOAG caused by a Tyr437His MYOC mutation.

Design

Case-control, immunohistochemical study of a donor eye from a patient with JOAG caused by a Tyr437His MYOC mutation and age-matched cont

SUBMITTER: van der Heide CJ 

PROVIDER: S-EPMC6425711 | biostudies-literature | 2018 Sep-Oct

REPOSITORIES: biostudies-literature