Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders.

ABSTRACT: Polychlorinated biphenyls (PCBs) are persistent organic pollutants that remain a human health concern with newly discovered sources of contamination and ongoing bioaccumulation and biomagnification. Children exposed during early brain development are at highest risk of neurological deficits, but highly exposed adults reportedly have an increased risk of Parkinson's disease. Our previous studies found allelic differences in the aryl hydrocarbon receptor and cytochrome P450 1A2 (CYP1A2) affect sensitivity to developmental PCB exposure, resulting in cognitive deficits and motor dysfunction. High-affinity Ahr ^b Cyp1a2(-/-) mice were most sensitive compared with poor-affinity Ahr ^d Cyp1a2(-/-) and wild-type Ahr ^b Cyp1a2(+/+) mice. Our follow-up studies assessed

SUBMITTER: Klinefelter K 

PROVIDER: S-EPMC6425730 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature