Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease.

ABSTRACT:

Background

It is unclear whether supplementation with vitamin D reduces the risk of cancer or cardiovascular disease, and data from randomized trials are limited.

Methods

We conducted a nationwide, randomized, placebo-controlled trial, with a two-by-two factorial design, of vitamin D₃ (cholecalciferol) at a dose of 2000 IU per day and marine n-3 (also called omega-3) fatty acids at a dose of 1 g per day for the prevention of cancer and cardiovascular disease among men 50 years of age or older and women 55 years of age or older in the United States. Primary end points were invasive cancer of any type and major cardiovascular events (a composite of myocardial infarction, stroke, or death from cardiovascular causes). Secondary end points included site-specific cancer

SUBMITTER: Manson JE 

PROVIDER: S-EPMC6425757 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature