A high methionine, low folate and vitamin B₆/B₁₂ containing diet can be associated with memory loss by epigenetic silencing of netrin-1.

ABSTRACT: Memory-epigenetics which is the loss of memory due to epigenetic modifications can be due to the silencing of genes involved in cognitive functions and this is the basis of the current study. We hypothesize that a diet containing high methionine and low vitamins can lead to memory impairment by increasing global DNA methylation and therefore, silencing the netrin-1 gene, which encodes the glycoprotein involved in neurogenesis, axonal guidance and maintenance of the synaptic plasticity. Wild type (C57BL/6J) mice were fed with a diet containing excess methionine (1.2%), low-folate (0.08 mg/kg), vitamin B₆ (0.01 mg/kg), and B₁₂ (10.4 mg/kg) for 6 weeks. Mice were examined weekly for the long-term memory function, using a passive avoidance test, which determined loss of f

SUBMITTER: Kalani A 

PROVIDER: S-EPMC6425846 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature