Wolbachia endosymbionts subvert the endoplasmic reticulum to acquire host membranes without triggering ER stress.

ABSTRACT: The reproductive parasites Wolbachia are the most common endosymbionts on earth, present in a plethora of arthropod species. They have been introduced into mosquitos to successfully prevent the spread of vector-borne diseases, yet the strategies of host cell subversion underlying their obligate intracellular lifestyle remain to be explored in depth in order to gain insights into the mechanisms of pathogen-blocking. Like some other intracellular bacteria, Wolbachia reside in a host-derived vacuole in order to replicate and escape the immune surveillance. Using here the pathogen-blocking Wolbachia strain from Drosophila melanogaster, introduced into two different Drosophila cell lines, we show that Wolbachia subvert the endoplasmic reticulum to acquire their vacuolar membrane and colonize th

SUBMITTER: Fattouh N 

PROVIDER: S-EPMC6426186 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature