Group B Streptococcus early-onset disease and observation of well-appearing newborns.

ABSTRACT:

Background

International guidelines lack a substantial consensus regarding management of asymptomatic full-term and late preterm neonates at risk for early-onset disease (EOS). Large cohorts of newborns are suitable to increase the understanding of the safety and efficacy of a given strategy.

Methods

This is a prospective, area-based, cohort study involving regional birth facilities of Emilia-Romagna (Italy). We compared cases of EOS (at or above 35 weeks' gestation) registered in 2003-2009 (baseline period: 266,646 LBs) and in 2010-2016, after introduction of a new strategy (serial physical examinations, SPEs) for managing asymptomatic neonates at risk for EOS (intervention period: 265,508 LBs).

Results

There were 108 cases of EOS (baseline period, n = 60; interventi

SUBMITTER: Berardi A 

PROVIDER: S-EPMC6426194 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature