Desialylation of platelets induced by Von Willebrand Factor is a novel mechanism of platelet clearance in dengue.

ABSTRACT: Thrombocytopenia and platelet dysfunction are commonly observed in patients with dengue virus (DENV) infection and may contribute to complications such as bleeding and plasma leakage. The etiology of dengue-associated thrombocytopenia is multifactorial and includes increased platelet clearance. The binding of the coagulation protein von Willebrand factor (VWF) to the platelet membrane and removal of sialic acid (desialylation) are two well-known mechanisms of platelet clearance, but whether these conditions also contribute to thrombocytopenia in dengue infection is unknown. In two observational cohort studies in Bandung and Jepara, Indonesia, we show that adult patients with dengue not only had higher plasma concentrations of plasma VWF antigen and active VWF, but that circulating platelet

SUBMITTER: Riswari SF 

PROVIDER: S-EPMC6426266 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature