A little goes a long way: Weak vaccine transmission facilitates oral vaccination campaigns against zoonotic pathogens.

ABSTRACT: Zoonotic pathogens such as Ebola and rabies pose a major health risk to humans. One proven approach to minimizing the impact of a pathogen relies on reducing its prevalence within animal reservoir populations using mass vaccination. However, two major challenges remain for vaccination programs that target free-ranging animal populations. First, limited or challenging access to wild hosts, and second, expenses associated with purchasing and distributing the vaccine. Together, these challenges constrain a campaign's ability to maintain adequate levels of immunity in the host population for an extended period of time. Transmissible vaccines could lessen these constraints, improving our ability to both establish and maintain herd immunity in free-ranging animal populations. Because the extent

SUBMITTER: Basinski AJ 

PROVIDER: S-EPMC6426267 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature