OptRAM: In-silico strain design via integrative regulatory-metabolic network modeling.

ABSTRACT: The ultimate goal of metabolic engineering is to produce desired compounds on an industrial scale in a cost effective manner. To address challenges in metabolic engineering, computational strain optimization algorithms based on genome-scale metabolic models have increasingly been used to aid in overproducing products of interest. However, most of these strain optimization algorithms utilize a metabolic network alone, with few approaches providing strategies that also include transcriptional regulation. Moreover previous integrated approaches generally require a pre-existing regulatory network. In this study, we developed a novel strain design algorithm, named OptRAM (Optimization of Regulatory And Metabolic Networks), which can identify combinatorial optimization strategies including overe

SUBMITTER: Shen F 

PROVIDER: S-EPMC6426274 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature