Partial pressure of arterial carbon dioxide after resuscitation from cardiac arrest and neurological outcome: A prospective multi-center protocol-directed cohort study.

ABSTRACT:

Aims

Partial pressure of arterial carbon dioxide (PaCO₂) is a regulator of cerebral blood flow after brain injury. We sought to test the association between PaCO₂ after resuscitation from cardiac arrest and neurological outcome.

Methods

A prospective protocol-directed cohort study across six hospitals.

Inclusion criteria

age ≥18, non-traumatic cardiac arrest, mechanically ventilated after return of spontaneous circulation (ROSC), and receipt of targeted temperature management. Per protocol, PaCO₂ was measured by arterial blood gas analyses at one and six hours after ROSC. We determined the mean PaCO₂ over this initial six hours after ROSC. The primary outcome was good neurological function at hospital discharge, defined a pr

SUBMITTER: Hope Kilgannon J 

PROVIDER: S-EPMC6426295 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature