More Evidence of Collusion: a New Prophage-Mediated Viral Defense System Encoded by Mycobacteriophage Sbash.

ABSTRACT: The arms race between bacteria and their bacteriophages profoundly influences microbial evolution. With an estimated 10²³ phage infections occurring per second, there is strong selection for both bacterial survival and phage coevolution for continued propagation. Many phage resistance systems, including restriction-modification systems, clustered regularly interspaced short palindromic repeat-Cas (CRISPR-Cas) systems, a variety of abortive infection systems, and many others that are not yet mechanistically defined, have been described. Temperate bacteriophages are common and form stable lysogens that are immune to superinfection by the same or closely related phages. However, temperate phages collude with their hosts to confer defense against genomically distinct phages, to the

SUBMITTER: Gentile GM 

PROVIDER: S-EPMC6426596 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature