Germline Variants in DNA Repair Genes, Diagnostic Radiation, and Risk of Thyroid Cancer.

ABSTRACT: Background: Radiation exposure is a well-documented risk factor for thyroid cancer; diagnostic imaging represents an increasing source of exposure. Germline variations in DNA repair genes could increase risk of developing thyroid cancer following diagnostic radiation exposure. No studies have directly tested for interaction between germline mutations and radiation exposure.Methods: Using data and DNA samples from a Connecticut population-based case-control study performed in 2010 to 2011, we genotyped 440 cases of incident thyroid cancer and 465 population-based controls for 296 SNPs in 52 DNA repair genes. We used multivariate unconditional logistic regression models to estimate associations between each SNP and thyroid cancer risk, as well as to directly estimate the genoty

SUBMITTER: Sandler JE 

PROVIDER: S-EPMC6426634 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature