Distinct myeloid cell subsets promote meningeal remodeling and vascular repair after mild traumatic brain injury.

ABSTRACT: Mild traumatic brain injury (mTBI) can cause meningeal vascular injury and cell death that spreads into the brain parenchyma and triggers local inflammation and recruitment of peripheral immune cells. The factors that dictate meningeal recovery after mTBI are unknown at present. Here we demonstrated that most patients who had experienced mTBI resolved meningeal vascular damage within 2-3 weeks, although injury persisted for months in a subset of patients. To understand the recovery process, we studied a mouse model of mTBI and found extensive meningeal remodeling that was temporally reliant on infiltrating myeloid cells with divergent functions. Inflammatory myelomonocytic cells scavenged dead cells in the lesion core, whereas wound-healing macrophages proliferated along the lesion perimet

SUBMITTER: Russo MV 

PROVIDER: S-EPMC6426637 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature