Deacylative transformations of ketones via aromatization-promoted C-C bond activation.

ABSTRACT: Carbon-hydrogen (C-H) and carbon-carbon (C-C) bonds are the main constituents of organic matter. Recent advances in C-H functionalization technology have vastly expanded our toolbox for organic synthesis¹. By contrast, C-C activation methods that enable editing of the molecular skeleton remain limited^2-7. Several methods have been proposed for catalytic C-C activation, particularly with ketone substrates, that are typically promoted by using either ring-strain release as a thermodynamic driving force^4,6 or directing groups^5,7 to control the reaction outcome. Although effective, these strategies require substrates that contain highly strained ketones or a preinstalled directing group, or are limited to more specialist substrate classes⁵

SUBMITTER: Xu Y 

PROVIDER: S-EPMC6426660 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature