Histone deacetylase enzymes as potential drug targets of Neglected Tropical Diseases caused by cestodes.

ABSTRACT: Cestode parasites cause neglected diseases, such as echinococcosis and cysticercosis, which represent a significant problem in human and animal health. Benzimidazoles and praziquantel are the only available drugs for chemotherapy and it is therefore important to identify new alternative drugs against cestode parasites. Histone deacetylases (HDACs) are validated drug targets for the treatment of cancer and other diseases, including neglected diseases. However, knowledge of HDACs in cestodes is very scarce. In this work, we investigated cestode HDACs as potential drug targets to develop new therapies against neglected diseases caused by cestodes. Here we showed the full repertoire of HDAC coding genes in several members of the class Cestoda. Between 6 and 7 zinc-dependent HDAC coding genes w

SUBMITTER: Vaca HR 

PROVIDER: S-EPMC6426703 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature