Intestinal Bacteria Interplay With Bile and Cholesterol Metabolism: Implications on Host Physiology.

ABSTRACT: Bile is a biological fluid synthesized in the liver, mainly constituted by bile acids and cholesterol, which functions as a biological detergent that emulsifies and solubilizes lipids, thereby playing an essential role in fat digestion. Besides, bile acids are important signaling molecules that regulate key functions at intestinal and systemic levels in the human body, affecting glucose and lipid metabolism, and immune homeostasis. Apart from this, due to their amphipathic nature, bile acids are toxic for bacterial cells and, thus, exert a strong selective pressure on the microbial populations inhabiting the human gut, decisively shaping the microbial profiles of our gut microbiota, which has been recognized as a metabolic organ playing a pivotal role in host health. Remarkably, bacteria i

SUBMITTER: Molinero N 

PROVIDER: S-EPMC6426790 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature