Microvascular density and hypoxia-inducible factor in intraepithelial vocal fold lesions.

ABSTRACT:

Objective

The promotion of neovascularisation is a crucial aspect of carcinogenesis. The study evaluates the microvascular density (MVD) and expression of hypoxia-induced factor (HIF-1α) in hypertrophic vocal fold (VF) lesions of different histopathological states including non-dysplastic, low-grade, high-grade dysplasia and invasive glottic cancer.

Materials and methods

Histological specimens collected from patients diagnosed and treated in a single centre with different histological grades were immunohistochemically stained with CD31, CD34 and HIF-1α. Of the total number of 77 analysed VF specimens, 20 were non-dysplastic, 20 had low-grade dysplasia, 17 high-grade dysplasia and 20 were invasive cancers.

Results

The highest mean value for MVD evaluated with expressio

SUBMITTER: Rzepakowska A 

PROVIDER: S-EPMC6426810 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature