The correlation and prognostic value of serum levels of soluble programmed death protein 1 (sPD-1) and soluble programmed death-ligand 1 (sPD-L1) in patients with hepatocellular carcinoma.

ABSTRACT:

Background

Blocking the programmed death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway in hepatocellular carcinoma (HCC) is a very promising approach in immunotherapy. However, the correlation and prognostic values of serum soluble PD-1 and PD-L1 (sPD-1/sPD-L1) have not been explored conjointly in HCC patients.

Methods

This study retrospectively included 120 HCC patients receiving radical resection. The serum levels of sPD-1/sPD-L1 and inflammatory cytokines were measured by antibody array assay. Immunohistochemistry was applied to assess both the expression of membrane-bound PD-L1, and the number of CD4⁺ tumor-infiltrating lymphocytes (TILs) and CD8⁺ TILs.

Results

The best cut-off values of sPD-1 and sPD-L1 for predicting disease-fr

SUBMITTER: Chang B 

PROVIDER: S-EPMC6426820 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature