Anti-oral Microbial Flavanes from Broussonetia papyrifera Under the Guidance of Bioassay.

ABSTRACT: A new flavane, bropapyriferol (1), and eleven known ones were isolated from the EtOAc part of Broussonetia papyrifera under the guidance of bioassay. The structure of compound 1 was determined by extensive 1D and 2D NMR, [α]_D spectroscopic data and quantum computation. Daphnegiravan F (2) and 5,7,3',4'-tetrahydroxy-3-methoxy-8,5'-diprenylflavone (3) showed significantly anti-oral microbial activity against five Gram-positive strains and three Gram-negative strains in vitro. Especially, compound 3 was more potent in suppressing Actinomyces naeslundii and Porphyromonas gingivalis (MIC = 1.95 ppm) than the positive control, triclosan.

SUBMITTER: Geng CA 

PROVIDER: S-EPMC6426910 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature