White matter microstructural abnormalities and default network degeneration are associated with early memory deficit in Alzheimer's disease continuum.

ABSTRACT: Instead of assuming a constant relationship between brain abnormalities and memory impairment, we aimed to examine the stage-dependent contributions of multimodal brain structural and functional deterioration to memory impairment in the Alzheimer's disease (AD) continuum. We assessed grey matter volume, white matter (WM) microstructural measures (free-water (FW) and FW-corrected fractional anisotropy), and functional connectivity of the default mode network (DMN) in 54 amnestic mild cognitive impairment (aMCI) and 46 AD. We employed a novel sparse varying coefficient model to investigate how the associations between abnormal brain measures and memory impairment varied throughout disease continuum. We found lower functional connectivity in the DMN was related to worse memory across AD conti

SUBMITTER: Ji F 

PROVIDER: S-EPMC6426923 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature