Human herpesvirus infections and dementia or mild cognitive impairment: a systematic review and meta-analysis.

ABSTRACT: Interest is growing in the role of infectious agents in the pathogenesis of dementia, but current evidence is limited. We conducted a systematic review and meta-analysis to investigate the effect of any of eight human herpesviruses on development of dementia or mild cognitive impairment (MCI). We searched the Cochrane Library, Embase, Global Health, Medline, PsycINFO, Scopus, Web of Science, clinical trials registers and grey literature sources from inception to December 2017 for observational studies with cohort, case control or self-controlled designs, or randomised controlled trials of interventions against herpesviruses. Pooled effect estimates and 95% confidence intervals (CIs) were generated through random effects meta-analyses across studies with the same design, outcome, and virus

SUBMITTER: Warren-Gash C 

PROVIDER: S-EPMC6426940 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature