A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma.

ABSTRACT: Low-passage, serum-free cell lines cultured from patient tumour tissue are the gold-standard for preclinical studies and cellular investigations of glioblastoma (GBM) biology, yet entrenched, poorly-representative cell line models are still widely used, compromising the significance of much GBM research. We submit that greater adoption of these critical resources will be promoted by the provision of a suitably-sized, meaningfully-described reference collection along with appropriate tools for working with them. Consequently, we present a curated panel of 12 readily-usable, genetically-diverse, tumourigenic, patient-derived, low-passage, serum-free cell lines representing the spectrum of molecular subtypes of IDH-wildtype GBM along with their detailed phenotypic characterisation plus a besp

SUBMITTER: Stringer BW 

PROVIDER: S-EPMC6427001 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature