Sequence variation at ANAPC1 accounts for 24% of the variability in corneal endothelial cell density.

ABSTRACT: The corneal endothelium is vital for transparency and proper hydration of the cornea. Here, we conduct a genome-wide association study of corneal endothelial cell density (cells/mm²), coefficient of cell size variation (CV), percentage of hexagonal cells (HEX) and central corneal thickness (CCT) in 6,125 Icelanders and find associations at 10 loci, including 7 novel. We assess the effects of these variants on various ocular biomechanics such as corneal hysteresis (CH), as well as eye diseases such as glaucoma and corneal dystrophies. Most notably, an intergenic variant close to ANAPC1 (rs78658973[A], frequency = 28.3%) strongly associates with decreased cell density and accounts for 24% of the population variance in cell density (β = -0.77 SD, P = 1.8 × 10^-314) and as

SUBMITTER: Ivarsdottir EV 

PROVIDER: S-EPMC6427039 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature