Carbohydrate Metabolic Compensation Coupled to High Tolerance to Oxidative Stress in Ticks.

ABSTRACT: Reactive oxygen species (ROS) are natural byproducts of metabolism that have toxic effects well documented in mammals. In hematophagous arthropods, however, these processes are not largely understood. Here, we describe that Rhipicephalus microplus ticks and embryonic cell line (BME26) employ an adaptive metabolic compensation mechanism that confers tolerance to hydrogen peroxide (H₂O₂) at concentrations too high for others organisms. Tick survival and reproduction are not affected by H₂O₂ exposure, while BME26 cells morphology was only mildly altered by the treatment. Furthermore, H₂O₂-tolerant BME26 cells maintained their proliferative capacity unchanged. We evaluated several genes involved in gluconeogenesis, glycolysis, a

SUBMITTER: Della Noce B 

PROVIDER: S-EPMC6427048 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature