A Draft Map of the Human Ovarian Proteome for Tissue Engineering and Clinical Applications.

ABSTRACT: Fertility preservation research in women today is increasingly taking advantage of bioengineering techniques to develop new biomimetic materials and solutions to safeguard ovarian cell function and microenvironment in vitro, and in vivo,. However, available data on the human ovary are limited and fundamental differences between animal models and humans are hampering researchers in their quest for more extensive knowledge of human ovarian physiology and key reproductive proteins that need to be preserved. We therefore turned to multi-dimensional label-free mass spectrometry to analyze human ovarian cortex, as it is a high-throughput and conclusive technique providing information on the proteomic composition of complex tissues like the ovary. In-depth proteomic profiling throug

SUBMITTER: Ouni E 

PROVIDER: S-EPMC6427241 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature