Mega-Analysis of Gray Matter Volume in Substance Dependence: General and Substance-Specific Regional Effects.

ABSTRACT:

Objective

Although lower brain volume has been routinely observed in individuals with substance dependence compared with nondependent control subjects, the brain regions exhibiting lower volume have not been consistent across studies. In addition, it is not clear whether a common set of regions are involved in substance dependence regardless of the substance used or whether some brain volume effects are substance specific. Resolution of these issues may contribute to the identification of clinically relevant imaging biomarkers. Using pooled data from 14 countries, the authors sought to identify general and substance-specific associations between dependence and regional brain volumes.

Method

Brain structure was examined in a mega-analysis of previously published data pooled f

SUBMITTER: Mackey S 

PROVIDER: S-EPMC6427822 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature