Genetic background modifies phenotypic and transcriptional responses in a C. elegans model of α-synuclein toxicity.

ABSTRACT:

Background

Accumulation of protein aggregates are a major hallmark of progressive neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease. Transgenic Caenorhabditis elegans nematodes expressing the human synaptic protein α-synuclein in body wall muscle show inclusions of aggregated protein, which affects similar genetic pathways as in humans. It is not however known how the effects of α-synuclein expression in C. elegans differs among genetic backgrounds. Here, we compared gene expression patterns and investigated the phenotypic consequences of transgenic α-synuclein expression in five different C. elegans genetic backgrounds.

Results

Transcriptome analysis indicates that α-synuclein expression effects pathways associated with nutrient storage, lipid

SUBMITTER: Wang YA 

PROVIDER: S-EPMC6427842 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature