SF-1 mediates reproductive toxicity induced by Cerium oxide nanoparticles in male mice.

ABSTRACT:

Background

Cerium oxide nanoparticles (CeO₂ NPs) have potential application for use in biomedical and in various consumer products. However, it is largely unclear whether CeO₂ NPs have effects on male reproductive function.

Methods

In this study, male mice were examined for toxicity, if any, following chronic oral administration of CeO₂ NPs for 32 days. In each animal, epididymides were examined for sperm motility and DNA integrity. Bloods were tested for testosterone levels. Testicular tissues were collected to determine the element Ce content, the daily sperm production (DSP), marker enzymes such as ACP, G6PD, γ-GT and SDH, mRNA expression levels of steroidogenesis genes Star, P450scc, P450c17, 3β-Hsd, and 17β-Hsd, as well as steroidogenic

SUBMITTER: Qin F 

PROVIDER: S-EPMC6427857 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature