Tunable enzyme responses in amphiphilic nanoassemblies through alterations in the unimer-aggregate equilibrium.

ABSTRACT: Developing design rules that offer tailorability in materials' response to enzymes is of great importance, as such materials are of interest in a variety of biomedical applications including sensing, diagnostics and drug delivery. Using an amphiphilic oligomeric platform, we show that the degree of polymerization and hydrophilic-lipophilic balance variations can be utilized to alter the unimer-aggregate equilibrium, which in turn offers robust tunability of the host-guest properties of the amphiphilic nanoassemblies. We found that oligomeric assemblies with higher degree of polymerization are less sensitive to enzymatic degradation and release the guest molecules at a slower rate. Similarly, increasing the hydrophilicity makes these assemblies more sensitive to enzymes. These trends can be

SUBMITTER: Gao J 

PROVIDER: S-EPMC6427939 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature