¹⁸F-THK5351 PET Imaging in Nonfluent-Agrammatic Variant Primary Progressive Aphasia.

ABSTRACT:

Background and purpose

To analyze ¹⁸F-THK5351 positron emission tomography (PET) scans of patients with clinically diagnosed nonfluent/agrammatic variant primary progressive aphasia (navPPA).

Methods

Thirty-one participants, including those with Alzheimer's disease (AD, n=13), navPPA (n=3), and those with normal control (NC, n=15) who completed 3 Tesla magnetic resonance imaging, ¹⁸F-THK5351 PET scans, and detailed neuropsychological tests, were included. Voxel-based and region of interest (ROI)-based analyses were performed to evaluate retention of ¹⁸F-THK5351 in navPPA patients.

Results

In ROI-based analysis, patients with navPPA had higher levels of THK retention in the Broca's area, bilateral inferior frontal l

SUBMITTER: Yoon CW 

PROVIDER: S-EPMC6428011 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature