Combined IL-2 Immunocomplex and Anti-IL-5 mAb Treatment Expands Foxp3⁺ Treg Cells in the Absence of Eosinophilia and Ameliorates Experimental Colitis.

ABSTRACT: Interleukin (IL)-2 is expressed during T cell activation and induces the proliferation and differentiation of T cells. CD4⁺Foxp3⁺ regulatory T cells (Tregs) constitutively express the high affinity IL-2 receptor (CD25/IL-2Rα) and rapidly respond to IL-2 to elaborate numerous suppressive mechanisms that limit immune-mediated pathologies. Accumulating evidence supports the concept that an aberrant balance between Tregs and Teff contribute to the pathology of intestinal inflammation and that the IL-2/Treg axis is a potential pathway to exploit for the treatment of inflammatory bowel disease (IBD). Here, we show that treatment of mice with IL-2/IL-2 antibody (JES6-1) immunocomplex during DSS-induced colitis induced Foxp3⁺ Treg expansion, but also potently stimu

SUBMITTER: Abo H 

PROVIDER: S-EPMC6428029 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature