Mitochondrion-targeted platinum complexes suppressing lung cancer through multiple pathways involving energy metabolism.

ABSTRACT: Mitochondria are potential therapeutic targets for anticancer drugs. A series of mitochondrion-targeted monofunctional platinum complexes, [Pt(ortho-PPh₃CH₂Py)(NH₃)₂Cl](NO₃)₂ (OPT), [Pt(meta-PPh₃CH₂Py)(NH₃)₂Cl](NO₃)₂ (MPT), and [Pt(para-PPh₃CH₂Py)(NH₃)₂Cl](NO₃)₂ (PPT) (PPh₃ = triphenylphosphonium, Py = pyridine), are studied in this article. The antitumor activity and mechanism of action have been investigated in vitro and in vivo as well as on molecular levels. OPT exhibits higher efficacy than cisplatin against A549 lung cancer cells; furthermore,

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC6428137 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature