Influence of cross-linking and retrograde flow on formation and dynamics of lamellipodium.

ABSTRACT: The forces that arise from the actin cortex play a crucial role in determining the membrane deformation. These include protrusive forces due to actin polymerization, pulling forces due to transient attachment of actin filaments to the membrane, retrograde flow powered by contraction of actomyosin network, and adhesion to the extracellular matrix. Here we present a theoretical model for membrane deformation resulting from the feedback between the membrane shape and the forces acting on the membrane. We model the membrane as a series of beads connected by springs and determine the final steady-state shape of the membrane arising from the interplay between pushing/pulling forces of the actin network and the resisting membrane tension. We specifically investigate the effect of the gel dynamics

SUBMITTER: Atakhani A 

PROVIDER: S-EPMC6428246 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature