Social Stress Affects Colonic Inflammation, the Gut Microbiome, and Short-chain Fatty Acid Levels and Receptors.

ABSTRACT:

Objectives

Gastrointestinal disorders, such as inflammatory bowel diseases (IBDs) and functional gastrointestinal disorders (FGIDs), involve disrupted homeostatic interactions between the microbiota and the host. Both disorders are worsened during stress, and in laboratory mice, stress exposure has been shown to change the composition of the gut microbiome. Stress-induced changes to the microbiome exacerbate intestinal inflammation and alter intestinal motility in mice. It is, however, not yet known whether microbiota-derived short-chain fatty acids (butyrate, propionate, and acetate) and their receptors contribute to this effect.

Methods

Mice were exposed to a social disruption stress, or left undisturbed as a control. After the first stress exposure, mice were orally chall

SUBMITTER: Maltz RM 

PROVIDER: S-EPMC6428608 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature