Methylome-wide association findings for major depressive disorder overlap in blood and brain and replicate in independent brain samples.

ABSTRACT: We present the first large-scale methylome-wide association studies (MWAS) for major depressive disorder (MDD) to identify sites of potential importance for MDD etiology. Using a sequencing-based approach that provides near-complete coverage of all 28 million common CpGs in the human genome, we assay methylation in MDD cases and controls from both blood (N = 1132) and postmortem brain tissues (N = 61 samples from Brodmann Area 10, BA10). The MWAS for blood identified several loci with P ranging from 1.91 × 10^-8 to 4.39 × 10^-8 and a resampling approach showed that the cumulative association was significant (P = 4.03 × 10^-10) with the signal coming from the top 25,000 MWAS markers. Furthermore, a permutation-based analysis showed significant overlap (P = 5.4 

SUBMITTER: Aberg KA 

PROVIDER: S-EPMC6428621 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature