Ontology highlight
ABSTRACT:
SUBMITTER: Steele CD
PROVIDER: S-EPMC6428691 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Cancer cell 20190301 3
Undifferentiated sarcomas (USARCs) of adults are diverse, rare, and aggressive soft tissue cancers. Recent sequencing efforts have confirmed that USARCs exhibit one of the highest burdens of structural aberrations across human cancer. Here, we sought to unravel the molecular basis of the structural complexity in USARCs by integrating DNA sequencing, ploidy analysis, gene expression, and methylation profiling. We identified whole genome duplication as a prevalent and pernicious force in USARC tum ...[more]