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Noninvasive monitoring of blood flow using a single magnetic microsphere.


ABSTRACT: Noninvasive medical imaging of blood flow relies on mapping the transit of a contrast medium bolus injected intravenously. This has the draw-back that the front of the bolus widens until the tissue of interest is reached and quantitative flow parameters are not easy to obtain. Here, we introduce high resolution (millimeter/millisecond) 3D magnetic tracking of a single microsphere locally probing the flow while passing through a vessel. With this, we successfully localize and evaluate diameter constrictions in an arteria phantom after a single passage of a microsphere. We further demonstrate the potential for clinical application by tracking a microsphere smaller than a red blood cell.

SUBMITTER: Liebl M 

PROVIDER: S-EPMC6428830 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Noninvasive monitoring of blood flow using a single magnetic microsphere.

Liebl Maik M   Gleich Bernhard B   Eberbeck Dietmar D   Radon Patricia P   Rahmer Jürgen J   Trahms Lutz L   Wiekhorst Frank F  

Scientific reports 20190321 1


Noninvasive medical imaging of blood flow relies on mapping the transit of a contrast medium bolus injected intravenously. This has the draw-back that the front of the bolus widens until the tissue of interest is reached and quantitative flow parameters are not easy to obtain. Here, we introduce high resolution (millimeter/millisecond) 3D magnetic tracking of a single microsphere locally probing the flow while passing through a vessel. With this, we successfully localize and evaluate diameter co  ...[more]

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