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A highly selective and recyclable NO-responsive nanochannel based on a spiroring opening-closing reaction strategy.

ABSTRACT: Endogenous nitric oxide (NO) is an important messenger molecule, which can directly activate K⁺ transmission and cause relaxation of vascular smooth muscle. Here, inspired by the K⁺ channel of smooth muscle cells, we report, a novel NO-regulated artificial nanochannel based on a spiro ring opening-closing reaction strategy. This nanofluidic diode system shows an outstanding NO selective response owing to the specific reaction between o-phenylenediamine (OPD) and NO on the channel surface with high ion rectification ratio (~6.7) and ion gating ratio (~4). Moreover, this NO gating system exhibits excellent reversibility and stability as well as high selectivity response. This system not only helps us understand the process of NO directly regulating biological ion channels, but also has potential application value in the field of biosensors.

SUBMITTER: Sun Y

PROVIDER: S-EPMC6428850 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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A highly selective and recyclable NO-responsive nanochannel based on a spiroring opening-closing reaction strategy.

Sun Yao Y Chen Sen S Chen Xiaoya X Xu Yuling Y Zhang Siyun S Ouyang Qingying Q Yang Guangfu G Li Haibing H

Nature communications 20190321 1

Endogenous nitric oxide (NO) is an important messenger molecule, which can directly activate K<sup>+</sup> transmission and cause relaxation of vascular smooth muscle. Here, inspired by the K<sup>+</sup> channel of smooth muscle cells, we report, a novel NO-regulated artificial nanochannel based on a spiro ring opening-closing reaction strategy. This nanofluidic diode system shows an outstanding NO selective response owing to the specific reaction between o-phenylenediamine (OPD) and NO on the c ...[more]

PMID: 30899007

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Project description:To overcome the time and space constraints in disease diagnosis via the biosensing approach, we developed a new signal-transducing strategy that can be applied to colorimetric optical biosensors. Our study is focused on implementation of a signal transduction technology that can directly translate the color intensity signals-that require complicated optical equipment for the analysis-into signals that can be easily counted with the naked eye. Based on the selective light absorption and wavelength-filtering principles, our new optical signaling transducer was built from a common computer monitor and a smartphone. In this signal transducer, the liquid crystal display (LCD) panel of the computer monitor served as a light source and a signal guide generator. In addition, the smartphone was used as an optical receiver and signal display. As a biorecognition layer, a transparent and soft material-based biosensing channel was employed generating blue output via a target-specific bienzymatic chromogenic reaction. Using graphics editor software, we displayed the optical signal guide patterns containing multiple polygons (a triangle, circle, pentagon, heptagon, and 3/4 circle, each associated with a specified color ratio) on the LCD monitor panel. During observation of signal guide patterns displayed on the LCD monitor panel using a smartphone camera via the target analyte-loaded biosensing channel as a color-filtering layer, the number of observed polygons changed according to the concentration of the target analyte via the spectral correlation between absorbance changes in a solution of the biosensing channel and color emission properties of each type of polygon. By simple counting of the changes in the number of polygons registered by the smartphone camera, we could efficiently measure the concentration of a target analyte in a sample without complicated and expensive optical instruments. In a demonstration test on glucose as a model analyte, we could easily measure the concentration of glucose in the range from 0 to 10 mM.

Dataset Information

A highly selective and recyclable NO-responsive nanochannel based on a spiroring opening-closing reaction strategy.

Publications

A highly selective and recyclable NO-responsive nanochannel based on a spiroring opening-closing reaction strategy.

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