A Genetic Risk Score for Atrial Fibrillation Predicts the Response to Catheter Ablation.

ABSTRACT:

Background and objectives

The association of susceptibility loci for atrial fibrillation (AF) with AF recurrence after ablation has been reported, although with controversial results. In this prospective cohort analysis, we aimed to investigate whether a genetic risk score (GRS) can predict the rhythm outcomes after catheter ablation of AF.

Methods

We determined the association between 20 AF-susceptible single nucleotide polymorphisms (SNPs) and AF recurrence after catheter ablation in 746 patients (74% males; age, 59±11 years; 56% paroxysmal AF). A GRS was calculated by summing the unweighted numbers of risk alleles of selected SNPs. A Cox proportional hazard model was used to identify the association between the GRS and risk of AF recurrence after catheter ablation.

Res

SUBMITTER: Choe WS 

PROVIDER: S-EPMC6428949 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature