Molecular Cloning and Bioinformatics Analysis of DQA Gene from Mink (Neovison vison).

ABSTRACT: In the present study, we cloned, sequenced, and explored the structural and functional characteristics of the major histocompatibility complex (MHC)-DQA gene from mink (Neovison vison) for the first time. The full-length sequence of DQA gene was 1147-bp-long, contained a coding region of 768-bp, which was predicted to encoding 255 amino acid residues. The comparison between DQA from mink (Neovison vison) and other MHC-DQA molecules from different animal species showed that nucleotide and encoded amino acid sequences of the mink DQA gene exhibited high similarity with the ferret (Mustela pulourius furo). Phylogenetic analysis revealed that mink (Neovison vison) DQA is grouped with that of ferret (Mustela pulourius furo). The cloned sequence contained a 23-amino acid NH₂-terminal signal sequ

SUBMITTER: Fan Z 

PROVIDER: S-EPMC6429307 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature