Self-assembling Peptide P₁₁-4 and Fluoride for Regenerating Enamel.

ABSTRACT: Regenerative medicine-based approaches for caries treatment focus on biomimetic remineralization of initial carious lesions as a minimal invasive therapy. In vitro, self-assembling peptide P₁₁-4 enhances remineralization of early carious lesions. To investigate the safety and clinical efficacy of P₁₁-4 for treatment of initial caries, a randomized controlled single-blind study was conducted on children aged >5 y with visible active early caries on erupting permanent molars. Subjects were randomized to either the test group (P₁₁-4 + fluoride varnish) or control group (fluoride varnish alone). Caries were assessed at baseline and at 3 and 6 mo posttreatment per laser fluorescence, a visual analog scale, the International Caries Detection and Assessment System

SUBMITTER: Alkilzy M 

PROVIDER: S-EPMC6429572 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature