Dataset Information
Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials.
Ontology highlight
ABSTRACT:
SUBMITTER: Cholesterol Treatment Trialists' Collaboration
PROVIDER: S-EPMC6429627 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials.
Lancet (London, England) 20190201 10170
<h4>Background</h4>Statin therapy has been shown to reduce major vascular events and vascular mortality in a wide range of individuals, but there is uncertainty about its efficacy and safety among older people. We undertook a meta-analysis of data from all large statin trials to compare the effects of statin therapy at different ages.<h4>Methods</h4>In this meta-analysis, randomised trials of statin therapy were eligible if they aimed to recruit at least 1000 participants with a scheduled treatm ...[more]