Clodronate-Loaded Liposome Treatment Has Site-Specific Skeletal Effects.

ABSTRACT: Ineffective oral wound healing is detrimental to patients' oral health-related quality of life. Delineating the cellular mechanisms involved in optimal healing will elicit better approaches to treating patients with compromised healing. Osteal macrophages have recently emerged as important positive regulators of bone turnover. The contributions of macrophages to long bone healing have been studied, but their role in oral osseous wound healing following tooth extraction is less clear. Clodronate-loaded liposomes were used as a tool to deplete macrophages in C57BL/6J mice and assess oral osseous bone fill after extraction. In addition to macrophage ablation, osteoclast ablation occurred. Interestingly, depletion of macrophages and osteoclasts via clodronate treatment had differential effects

SUBMITTER: Michalski MN 

PROVIDER: S-EPMC6429666 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature