SSS-test: a novel test for detecting positive selection on RNA secondary structure.

ABSTRACT:

Background

Long non-coding RNAs (lncRNAs) play an important role in regulating gene expression and are thus important for determining phenotypes. Most attempts to measure selection in lncRNAs have focused on the primary sequence. The majority of small RNAs and at least some parts of lncRNAs must fold into specific structures to perform their biological function. Comprehensive assessments of selection acting on RNAs therefore must also encompass structure. Selection pressures acting on the structure of non-coding genes can be detected within multiple sequence alignments. Approaches of this type, however, have so far focused on negative selection. Thus, a computational method for identifying ncRNAs under positive selection is needed.

Results

We introduce the SSS-test (test for

SUBMITTER: Walter Costa MB 

PROVIDER: S-EPMC6429701 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature