Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers.

ABSTRACT:

Background

The Centiloid scale has been developed to standardize measurements of amyloid PET imaging. Reference cut-off values of this continuous measurement enable the consistent operationalization of decision-making for multicentre research studies and clinical trials. In this study, we aimed at deriving reference Centiloid thresholds that maximize the agreement against core Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers in two large independent cohorts.

Methods

A total of 516 participants of the ALFA+ Study (N = 205) and ADNI (N = 311) underwent amyloid PET imaging ([¹⁸F]flutemetamol and [¹⁸F]florbetapir, respectively) and core AD CSF biomarker determination using Elecsys® tests. Tracer uptake was quantified in Centiloid units (CL). Op

SUBMITTER: Salvado G 

PROVIDER: S-EPMC6429814 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature