Critical appraisal of adverse effects reporting in the 'Treatment for Adolescents With Depression Study (TADS)'.

ABSTRACT: OBJECTIVE:To identify all publications from the 'Treatment for Adolescents With Depression Study (TADS)' and assess the findings regarding occurrence of any adverse effects in the treatment groups both for the short-term and long-term study stages. DESIGN:Descriptive analysis of TADS publications with any information on adverse effects. RESULTS:We identified 48 publications describing various aspects of the TADS, in which 439 adolescent patients received treatment with fluoxetine, cognitive-behavioural therapy, cognitive-behavioural therapy plus fluoxetine or placebo. Eight publications were assessed as providing some data on adverse effects. Risk of suicidal behaviour was the only adverse effect that was addressed in all publications. Several psychiatric and physical adverse effects were

SUBMITTER: Westergren T 

PROVIDER: S-EPMC6429903 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature